Thank you Robin. This is the first I recall hearing about lignans.
A quick search online gave me three impressions: (1) lignans are not the same as lignins; (2) defining lignans quickly gets into organic chemistry; and (3) lignans in the human diet (they come from plants) are often referred to in positive terms,
In fact, I had a hard time finding negative takes on lignans, and those related to very high consumption of flax (one of the foods particularly high in these compounds; all grain, including millets and sorghum, have lignans, but at more moderate levels). Can you give us more info, Robin?
Here's a definition of lignans that I found helpful (many, including the one in WIkipedia,/1 are more technical):
"The lignans are bioactive, non-nutrient, non-caloric phenolic plant compounds that are found in highest concentration in flax and sesame seeds and in lower concentrations in grains, other seeds, fruits and vegetables. The enterolignans (sometimes referred to as mammalian lignans) are metabolites of food lignans produced by human intestinal bacteria. They have been identified in human urine and plasma. Their weak estrogenic and other biochemical properties suggest potential for nutritional significance in the prevention of cardiovascular and other chronic diseases."/2
Regarding millets a different article states:
"Millets are rich in lignans, upon digestion they can be converted into animal lignans by gut microbiota, and those animal lignans have been shown to protect against certain chronic diseases, like cancer and heart disease."/3
Sorghum apparently does contain lignans./4
In general, "Lignan-rich foods are part of a healthy diet"/5 Various research articles explore specific positive effects of lignans, including for cardiovascular health,/2 stress perception,/6 and possibly pot-menopausal symptoms./7 I see some suggestions of anti-cancer effects./3 /7 Lignans have an important role in gut microbiota, apparently with implications for health in various ways./8
The above is neither comprehensive, nor necessarily representative with regard to the thinking about lignans, but as a non-specialist in this field, this is what I came up with. It's important to note that lignans are a class of compounds, and not one single thing, so perhaps there are differences in the effects of various lignins? Interested to learn more.
Don
Notes:
3. Babele, Piyoosh K et al. “Mainstreaming orphan millets for advancing climate smart agriculture to secure nutrition and health.” Frontiers in plant science vol. 13 902536. 12 Aug. 2022,
https://doi.org/10.3389/fpls.2022.9025366. Micek, Agnieszka et al. “Negative Association
of Lignan and Phytosterol Intake with Stress Perception during the
COVID-19 Pandemic-A Polish Study on Young Adults.”
Nutrients vol. 16,3 445. 2 Feb. 2024,
https://doi.org/10.3390/nu160304457. Jang, Won Young et al. “Antioxidant,
Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans
and Their Metabolites.”
International journal of molecular sciences vol. 23,24 15482. 7 Dec. 2022,
https://doi.org/10.3390/ijms2324154828. Senizza, Alice et al. “Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications.” Molecules (Basel, Switzerland) vol. 25,23 5709. 3 Dec. 2020,
https://doi.org/10.3390/molecules25235709